Macrolide lactams
TARGETMOL CHEMICALS INC FK-453 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. FK-453 is a potent antagonist of non-xanthine adenosine A1 receptor with diuretic and renal vasodilatory activity. purity: 99%
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mM (in 1mL DMSO), CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Sigma Aldrich Fine Chemicals Biosciences Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | 109581-93-3 | MFCD11045918 |
Tacrolimus for system suitability European Pharmacopoeia (EP) Reference Standard | Mol Wt: 822.03 | 109581-93-3 | MFCD11045918 |
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
eMolecules Ascomycin | 104987-12-4 | | 1g
Combi-Blocks | Ascomycin | 1g | 296391981 | QA-7570 | 96.000 | 104987-12-4 | | 792.020 | C43H69NO12
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TARGETMOL CHEMICALS INC Tacrolimus 100MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 200 mg, 500 mg and bulk. Please contact Fisher for quotes. Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein phosphatase. Purity 99.87%
Medchemexpress LLC FK 453 | 121524-18-3 | 99.2% | 375.46 | C23H25N3O2 | 25 MG
FK 453 is a research-use adenosine A1 receptor antagonist (compound 1d) characterized by potent activity and a defined chemical profile. It exhibits an IC50 of 17.2 nM and is supplied as a high-purity powder with recommended storage conditions for both powder and solution forms.
- Potent, selective adenosine A1 receptor antagonist (IC50 = 17.2 nM).
- High purity: 99.2%.
- Molecular formula C23H25N3O2 and molecular weight 375.46.
- Available in multiple small-scale package sizes, including 25 mg.
- Storage recommended as powder at -20°C (3 years) or 4°C (2 years).
- In solvent storage guidance: -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical use.
Apexbio Technology LLC Ascomycin(FK 520) 104987-12-4 100mg
Ascomycin FK 520 (CAS 104987-12-4) is a small-molecule immunosuppressant targeting calcineurin phosphatase via binding to immunophilin FKBP12 It is designed to inhibit calcineurin activity thereby suppressing NFAT-mediated T-cell activation and proliferation Ascomycin FK 520 exerts its biological activity primarily by forming a complex with FKBP12 that inhibits calcineurin phosphatase In in vitro assays Ascomycin FK 520 demonstrates dose-dependent inhibition of lymphocyte responsiveness with an IC50 in the submicromolar range and no cytotoxicity observed below 3 2 M In animal models administration at doses 3 2 mg/kg prolongs skin transplant survival in rats Based on these pharmacological properties Ascomycin FK 520 holds research potential in studies of calcineurin-mediated immune responses and the development of T-cell modulation strategies
Medchemexpress LLC Tacrolimus | 104987-11-3 | MFCD00869853 | 99.6% | C44H69NO12 | 10MG
Tacrolimus (Standard) is an analytical reference standard of tacrolimus (FK506) intended for research and analytical laboratories. It is used for calibration, method development, and qualitative or quantitative analyses by techniques such as HPLC, GC, and mass spectrometry, and is supplied with supporting documentation for analytical use.
- High purity (99.6%) suitable for trace-level quantitation.
- Compatible with HPLC, GC, and MS analytical methods.
- Supplied as an analytical standard for calibration and method development.
- Certificate of analysis and safety data sheet available.
- Available in multiple small pack sizes for analytical workflows.
Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 10mM (in 1mL DMSO)
Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies
Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 500mg
Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 5mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
AdipoGen FK-506 Tacrolimus
Chemical. CAS 109581-93-3. Formula C44H69NO12 . H2O. MW 804.0 . 18.0. Isolated from Streptomyces FCZ0311. Potent immunosuppressant as cyclosporin A and rapamycin. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 IL-2. Forms a complex with FK-506 binding protein 12 FKBP12. Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B PP2B calcineurin, leading to disruption of T cell activation. Prevents rejection of transplanted organs. Anti-inflammatory compound in the treatment of several inflammatory skin diseases e.g. atopic dermatitis and with potential anti-rheumatic activity rheumatoid arthritis. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2 release compound. NF-kappaB suppressor by induction of unfolded protein response UPR. Anti-cancer compound. Apoptosis inducer.