Macrolide lactams
TARGETMOL CHEMICALS INC Tacrolimus monohydrate 100MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 500 mg and bulk. Please contact Fisher for quotes. Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties. It prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro and has strong immunosuppressive activity in vivo. Purity 99.2%
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 5mg, CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Abcam FK506 (Tacrolimus), Immunosuppressant, 10MG
MW 804 Da, Purity >98%. Immunosuppressant. Complexes with FKBP-12 to inhibit calcineurin. Achieve your results faster with highly validated, pure and trusted compounds.
The product is subject to the following: Abcam Restricted Use Statement
Apexbio Technology LLC Tacrolimus (FK506) 104987-11-3 10mM (in 1mL DMSO)
Tacrolimus (FK506) is a macrolide immunosuppressant that acts as a potent inhibitor of calcineurin thereby selectively suppressing T-cell activation Mechanistically tacrolimus forms a complex with FKBP12 protein which binds to calcineurin and inhibits phosphatase activity subsequently blocking the transcription and secretion of cytokines notably interleukin-2 (IL-2) IL-3 IL-4 and interferon- Tacrolimus demonstrates an IC50 range between 0 1 1 nM in inhibiting IL-2 secretion in cellular assays Due to this mode of action it is commonly utilized in biomedical research focusing on T-cell response modulation cytokine-mediated signaling pathways transplantation immunology and autoimmune disease models both in vitro and in animal transplant studies
Selleck Chemical LLC Tacrolimus (FK506) S5003-1g
Tacrolimus (FK506) is a 23-membered macrolide lactone it reduces peptidyl-prolyl isomerase activity in T cells by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex Tacrolimus also inhibits the phosphatase activity of calcineurin Tacrolimus induces vascular endothelial autophagy
Apexbio Technology LLC FK 866 hydrochloride(Synonyms: FK866 hydrochloride, APO866 hydrochloride, Daporinad hydrochloride), 10mM (in 1mL DMSO), CAS: 658084-64-1 (free base).
FK 866 hydrochloride (CAS 658084-64-1 free base) is a potent inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase) an enzyme essential for NAD biosynthesis exhibiting activity with IC50 values ranging from 0 09 nM to 27 2 nM By blocking NAD synthesis FK 866 disrupts ATP production induces mitochondria membrane depolarization and triggers autophagy independent of caspase activation It selectively targets hematologic cancer cells such as AML lines sparing normal hematopoietic progenitor cells FK 866 demonstrates antitumor efficacy in vivo significantly suppressing growth in AML-M4 and Namalwa xenograft models
Selleck Chemical LLC Tacrolimus monohydrate
Tacrolimus monohydrate (Tacrolimus FK506) is a macrolide antibiotic that primarily acts as an inhibitor of calcineurin phosphatase by binding to FK506 binding protein (FKBP) This inhibition blocks calcium-dependent processes including interleukin-2 gene transcription nitric oxide synthase activation cell degranulation and apoptosis and also has immunosuppressive neuroregenerative and neuroprotective properties
TARGETMOL CHEMICALS INC Ascomycin 500MG
Also available in 1 mL, 5 mg, 10 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Ascomycin (Immunomycin)(Immunomycin, FR-900520, FK520) is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. Purity 99.94%
Apexbio Technology LLC Tacrolimus monohydrate 109581-93-3 500mg
Tacrolimus monohydrate also identified as FK506 monohydrate is a macrolide immunosuppressive compound functioning via inhibition of calcineurin-mediated signaling pathways Specifically tacrolimus forms a complex with FK506-binding protein (FKBP12) subsequently blocking calcineurin phosphatase activity thus suppressing T-cell activation and diminishing interleukin-2 (IL-2) transcription levels In cellular assays tacrolimus demonstrates inhibition of calcineurin with IC50 values typically ranging between 0 1-1 0 nM Due to its targeted modulation of immune signaling this compound remains widely utilized in biomedical research particularly for investigations related to immune response mechanisms autoimmune disorder models transplantation biology and signal transduction pathways relevant to lymphocyte activation and cytokine expression
TARGETMOL CHEMICALS INC FK 3311 25MG
Also available in 1 mL, 2 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes. FK 3311 (COX-2 Inhibitor V) is an orally available, cell-permeable sulfonanilide that functions as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (NSAID). Purity 97.3%